Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice

A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice

Targeted delivery of self-antigens to the immune system in a mode that stimulates a tolerance-inducing pathway has proven difficult. To address this hurdle, we developed a vaccine based-approach comprised of two synthetic controlled-release biomaterials, poly(lactide-co-glycolide; PLGA) microparticles (MPs) encapsulating denatured insulin (key self-antigen in type 1 diabetes; T1D), and PuraMatr...

Insulin-independent reversal of type 1 diabetes in non-obese diabetic mice with brown

Amelioration of type 1 diabetes following treatment of non-obese diabetic mice with INGAP and lisofylline.

Type 1 diabetes mellitus results from the autoimmune and inflammatory destruction of insulin-producing islet β cells, rendering individuals devoid of insulin production. Recent studies suggest that combination therapies consisting of anti-inflammatory agents and islet growth-promoting factors have the potential to cause sustained recovery of β cell mass, leading to amelioration or reversal of t...

Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling

Rotavirus infection is associated with childhood progression to type 1 diabetes. Infection by monkey rotavirus RRV accelerates diabetes onset in non-obese diabetic (NOD) mice, which relates to regional lymph node infection and a T helper 1-specific immune response. When stimulated ex vivo with RRV, plasmacytoid dendritic cells (pDCs) from naïve NOD mice secrete type I interferon, which induces ...

Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice.

Type 1 diabetes (T1D) results from the autoimmune-mediated destruction of pancreatic β-cells, leading to deficiency of insulin production. Successful islet transplantation can normalise hyperglycaemia in T1D patients; however, the limited availability of the islets, loss of islet cell mass through apoptosis after islet isolation and potential autoimmune destruction of the transplanted islets pr...